Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney

Table 1

Systemic characteristics and single-kidney function in study groups at 16 weeks.

	Lean	MetS	MetS+RAS	MetS+RAS+ LeanEVs	MetS+RAS+ MetS-EVs
Body weight (kg)
MAP (mmHg)
Degree of stenosis (%)	0	0	†	†	†
Total cholesterol (mg/dl)	84.5 (78.0-90.1)	328.0 (315.1-481.1)	345.2 (321.2-406.2)	345.2 (323.7-413.1)	316.5 (310.5-329.5)
LDL cholesterol (mg/dl)
Triglycerides (mg/dl)	7.6 (5.9-8.7)	17.3 (13.0-22.5)	15.1 (14.2-16.1)	16.7 (12.9-17.3)	14.8 (12.4-17.0)
Fasting glucose (mg/dl)
Fasting insulin (μU/ml)	0.4 (0.4-0.5)	0.8 (0.7-0.8)	0.8 (0.7-0.8)	0.8 (0.7-0.8)	0.7 (0.7-0.8)
HOMA-IR score	0.6 (0.5-0.7)	1.9 (1.5-1.9)	1.8 (1.7-1.8)	1.7 (1.7-1.8)	1.8 (1.5-1.9)
Renal volume (ml)			†	‡	†#
RBF (ml/min)			†	‡	†#
GFR (ml/min)			†	‡	†#

MAP: mean arterial pressure; LDL: low-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; RBF: renal blood flow; GFR: glomerular filtration rate. vs. Lean; † vs. MetS; ‡ vs. MetS + RAS; # vs. MetS+RAS+Lean-EVs.