Symbol Entrez gene name Fold change Molecule type Group Fold change upregulated S100A4 S100 calcium binding protein A4 2.805862 0.0426795 Calcium binding protein Cell cycle and oncogenes CDH1 Cadherin 1, type 1, E-cadherin (epithelial) 1.61272 0.0221517 Cell adhesion molecule BRCA2 Breast cancer 2, early onset 1.36718 0.0158221 DNA repair SMG6 Smg-6 homolog, nonsense mediated mRNA decay factor (C, elegans) 1.1617644 0.0169296 Enzyme FGF9 Fibroblast growth factor 9 (glia-activating factor) 6.6313844 0.0116976 Growth and differentiation factor HOX, SOCS, Notch signaling IL-33 Interleukin-33 2.8804057 0.0380778 Cytokine HOXA11 Homeobox A11 2.00343 0.0164048 Transcription factor BMP4 Bone morphogenetic protein 4 1.8365396 0.0429056 Growth and differentiation factor PODXL Podocalyxin-like 4.6124125 0.0230397 Cell differentiation Differentiation and lineage CTSK Cathepsin K 2.5564253 0.0201834 Lysosomal cysteine protease CSF1 Colony stimulating factor 1 (macrophage) 2.176855 0.0155533 Cytokine TGFB3 Transforming growth factor, beta 3 1.8547666 0.0230397 Growth and differentiation factor NRP1 Neuropilin 1 1.7981821 0.0058021 Membrane-bound coreceptor GDF10 Growth differentiation factor 10 1.6743402 0.0155533 Growth and differentiation factor FGF9 Fibroblast growth factor 9 (glia-activating factor) 6.6313844 0.0143408 Growth and differentiation factor Stemness ZFPM2 Zinc finger protein, multitype 2 5.1527076 0.0195738 Transcription factor MME Membrane metallo-endopeptidase 3.1862447 0.0245681 Enzyme FZD4 Frizzled homolog 4 (drosophila) 2.4862442 0.0143408 Receptor ACVRL1 Activin A receptor type II-like 1 1.8575617 0.0143408 Enzyme Fold change downregulated SMAD3 SMAD family member 3 -2.579574 0.0108465 Transcriptional modulator Cell cycle and oncogenes CDK6 Cyclin-dependent kinase 6 -2.243104 0.0237225 Enzyme KRAS|LYRM5 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog|LYR motif containing 5 -1.901833 0.0461384 Proto-oncogene TGFB1 Transforming growth factor, beta 1 -1.731404 0.0158221 Growth and differentiation factor RARA Retinoic acid receptor, alpha -1.566421 0.0337291 Nuclear receptor HUS1 Checkpoint protein HUS1 -1.287702 0.0108465 Genotoxin-activated checkpoint complex SUN1|C7orf20 Sad1 and UNC84 domain containing 1|chromosome 7 open reading frame 20 -1.263087 0.0108465 Nuclear envelope protein PURA Purine-rich element binding protein A -1.253684 0.0108465 Multifunctional DNA- and RNA-binding protein CDON Cdon homolog (mouse) -1.5534242 0.0691849 Cell surface receptor HOX, SOCS, Notch signaling HOXA2 Homeobox A2 -1.6179696 0.0280393 Transcription factor SNAI1 Snail homolog 1 (drosophila) -1.6272678 0.0442530 Transcription factor PYGO1 Pygopus homolog 1 (drosophila) -1.6621072 0.0924799 NOTCH2 Notch homolog 2 (drosophila) -1.6733813 0.0177410 Transmembrane protein MAML2 Mastermind-like 2 (drosophila) -1.6876673 0.0481715 Transcriptional coactivator VCAM1 Vascular cell adhesion molecule 1 -17.354261 0.0058021 Differentiation and lineage ACAN Aggrecan -5.5746202 0.0192411 EGR2 Early growth response 2 -4.387574 0.0191151 TGFB2 Transforming growth factor, beta 2 -3.9135396 0.0058021 IGF2|INS-IGF2 Insulin-like growth factor 2 (somatomedin A)|INS-IGF2 readthrough transcript -3.4904327 0.0192411 BMP2 Bone morphogenetic protein 2 -3.314717 0.0230696 BDNF Brain-derived neurotrophic factor -3.2864723 0.0155533 JAG1 Jagged 1 (Alagille syndrome) -3.0462105 0.0058021 INHBA Inhibin, beta A -2.8667028 0.0422998 ITGA3 Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -2.775381 0.0155533 SMAD3 SMAD family member 3 -2.5795743 0.0078861 HES1 Hairy and enhancer of split 1 (drosophila) -2.220433 0.0192411 EFNB2 Ephrin-B2 -2.1113176 0.0358564 PTN Pleiotrophin -2.1063795 0.0155533 PDGFA LOC100132080 Platelet-derived growth factor alpha polypeptide|hypothetical LOC100132080 -2.0340111 0.0155533 LIF|MGC20647 Leukemia inhibitory factor (cholinergic differentiation factor)|hypothetical protein MGC20647 -9.517681 0.0154874 Stemness CXCL12 Chemokine (C-X-C motif) ligand 12|chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) -8.499458 0.0414186 MCAM Melanoma cell adhesion molecule -5.909656 0.0080718 ACAN Aggrecan -5.5746202 0.0193145 LTBP1 Latent transforming growth factor beta binding protein 1 -4.3929467 0.0398936 BMP2 Bone morphogenetic protein 2 -3.314717 0.0236414 SMAD3 SMAD family member 3 -2.5795743 0.0087946 ALCAM Activated leukocyte cell adhesion molecule -2.1179285 0.0080718 ITGAV Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) -2.0977302 0.0143408 GDF6 Growth differentiation factor 6 -2.054666 0.0427049 FGF7 Fibroblast growth factor 7 (keratinocyte growth factor) -2.0363815 0.049803 FGFR2 Fibroblast growth factor receptor 2 -1.8906314 0.0324610
