Stem Cells International

Research Article

Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway

Table 1

Characteristics of patients.


	All patients	MDS patients		IO MDS/AML patients
	All patients	IO group	NIO group	IO MDS/AML patients

(%)	53	18 (34.0%)	22 (41.5%)	13 (24.5%)
Median age (years)	61 ()	56 ()	57.5 ()	64 ()
Gender
Male	23	9	7	7
Female	30	9	15	6
Ferritin (ng/ml)	1119.2 ()	2000 ()	427.28 ()	1831.1 ()
2016 WHO classification
SLD	1	0	1
RS	2	1	1
MLD	10	6	4
EB-1	10	3	7
EB-2	17	8	9
IPSS-R
Mediate risk	17	8	9
High risk	13	4	9
Very high risk	10	6	4

No significant difference was found in the distribution of gender, WHO classification, and IPSS-R between the NIO MDS group and the IO MDS group (). IO: iron overload; NIO: noniron overload; MDS/AML: MDS transformation to AML.