Research Article
Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System
Figure 5
Protein and gene expression of Bcl-2, Bax, and caspase-3 in human islets cocultured with Hpc-MSCs and Nc-MSCs. (a–c) Bax, Bcl-2, and active caspase-3 protein in the islets expressed as graphs based on the H-score method. (d–f) Bax, Bcl-2, and caspase-3 mRNA expression in the islets. A comparison was done between the control and each cocultured islets. , , and . Nc-MSCs: normoxia condition mesenchymal stem cells; Hpc-MSCs: hypoxia preconditioning MSCs; D: direct coculture; I: indirect coculture.
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