Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance
KDM4C is required for stem cell properties of ovarian cancer cells. (a–c) Sphere formation ability of SK-OV-3 and HO-8910 cells was inhibited after KDM4C depletion. Scale bar, 100 μm. (d–f) Colony-forming ability was decreased after knockdown of KDM4C in SK-OV-3 and HO-8910 cells. (g) The percentage of the ALDHhigh population in SK-OV-3 and HO-8910 cells was reduced after knockdown of KDM4C. .