The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors

<div>Study on the effect of <i>CASP4</i> and NLRP1 genes on MCF7 pyroptosis induced by hUCMSC-CM. (a) The western blotting results of pro-CASP1, cleaved-CASP1, and ASC proteins. (b) The western blotting results of pro-CASP4 and cleaved-CASP4. (c) The western blotting results of NLRP1. (d) The concentration of secreted cytokine in cell supernatant. NC: negative control. CM-: cells were collected after transfection with shRNA vector for 72 h. CM+: cells were collected after transfection with shRNA vector for 72 h and treated with hUCMSC-CM for 24 h. C: cells were collected after transfection with shRNA vector for 72 h. T: cells were collected after transfection with shRNA vector for 72 h and treated with hUCMSC-CM for 24 h. 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Stem Cells International

fig6

Figure 6

Figure 6: The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors 