Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance
Different antioxidant capacity between CD44+CD133- and CD44+CD133+ cells. (a) Representative histograms of flow cytometry analysis show the intracellular ROS levels 24 hr after the treatment by 10 μM DXR, in the absence or presence of 50 μM verapamil. The results were reproducible in three independent experiments. (b) Representative blots and semiquantitative data on the expression of Nrf2 in cells treated with 10 μM DXR, in the absence or presence of 50 μM verapamil. The quantitative data are normalized to β-tubulin. Data are expressed as relative values to CD44+CD133- cells without DXR treatment and presented as the from three independent experiments.
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