Plasmatic Membrane Expression of Adhesion Molecules in Human Cardiac Progenitor/Stem Cells Might Explain Their Superior Cell Engraftment after Cell Transplantation

Figure 1

Improvement of left ventricular function in CPC-treated animals 4 weeks after transplantation. (a) Quantified values of fractional area change (FAC, %), fractional shortening (FS, %), and anterior wall thickening (AWT, %) from the control, BM-MSC, and CPC animal groups measured in 2D and M-Mode imaging 4 weeks after myocardial infarction ( in each group). (b) Representative images of heart sections from infarcted rats stained with Masson’s trichrome. Fibrotic area in the left ventricle is stained in blue. (c) Quantification of the fibrotic area represented as the percentage scar tissue. (d) Quantification of the left ventricular wall (LVW) thickness in millimeters. Data are represented as . , , and . (e) Detection of transplanted CPCs after transplantation in infarcted rats at different time points. Percentage of rats in which human Alu-DNA was detected in the indicated organs on days: 2 (red), 10 (green), and 21 (black) after myocardial infarction. .

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