| | Epigenetic modifiers | Epigenetic marks | Targets | Differentiation |
| | Histone methylation | | EZH2 | H3K27me3 | Wnt/β-catenin pathway | Inflammation, proliferation, osteogenic [110, 111] | | EHMT1 | H3K9me2 | RUNX2 | Osteogenic [113] | | MLL | H3K4me3 | Wnt5a | Odontogenic [119] | | Histone demethylation | | KDM5A | H3K4me3 | DMP1, DSPP, OSX, and OCN | Odontogenic [121] | | KDM6B | H3K27me3 | Wnt5a, BMP2 | Osteo/odontogenic [116, 117, 119] | | Histone acetylation | | HAT | H3 acetylation | DSPP | Odontogenic [125] | | p300 | H3K9ac | NANOG, SOX2, DSPP, OCN, Dmp1, and Sp7 | Pluripotency, proliferation, odontogenic [126, 127, 132, 134] | | Histone deacetylation | | HDAC3 | H3K27ac | Dmp1, Sp7 | Odontogenic [132, 134] | | HDAC6 | | | Odontogenic [131] |
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