High Dose of Intravenous Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells (CLV-100) Infusion Displays Better Immunomodulatory Effect among Healthy Volunteers: A Phase 1 Clinical Study

Table 3

Baseline and follow-up clinical assessments among subjects in the LD group.

Parameters	Baseline day 0	Follow-up period				value^a
		Day 2	Day 30	Day 90	Day 180
Routine blood tests
WBC (×10^9/L)						0.51
Hemoglobin (g/dL)						0.74
Creatinine (umol/L)						0.97
HCT (%)						0.59
MCV (fl)						0.72
Platelet (×10^9/L)						0.96
ESR (mm/hr)						0.69
AST (IU/L)						0.34
ALT (IU/L)						0.92
Albumin (g/L)						0.07
Globulin (g/L)						0.96
A/G ratio						0.06
Total cholesterol (mmol/L)						0.59
HbA1c (%)		—				0.78
FBS (mmol/L)		—				0.64
Insulin (mU/L)		—				0.68
IGF-1 (ng/mL)		—				0.62
DHEAS (μmol/L)		—				0.46
Estradiol (pg/mL)		—				0.90
Progesterone (ng/mL)		—				0.52
Testosterone (ng/mL)	-^b	—	-^b	-^b	-^b	-^b
hs-CRP (mg/L)						0.03
IgE (IU/mL)						0.14
Total PSA (ng/mL)		—				0.90
CA125 (U/mL)		—				0.90
CA15.3 (U/mL)		—				0.82
CEA (ng/mL)		—				0.23
CA19.9 (U/mL)		—				0.52
AFP (ng/mL)		—				0.14
Vital signs
SBP (mmHg)						0.89
DBP (mmHg)						0.21
Heart rate (beats/min)						0.40
Lung function tests
FEV1 (L)		—	—			0.13
FVC (L)		—	—			0.82
FEV1/FVC (%)		—	—			0.25
Biomarkers
IL-6 (pg/mL)				—		0.56
IL-10 (pg/mL)				—		0.21
PGE2 (pg/mL)				—		0.76
IL1-RA (pg/mL)				—		0.22
TNF-α (pg/mL)				—		0.06
TGF-β (ng/mL)				—		0.54
VEGF (pg/mL)				—		0.27
HGF (pg/mL)				—		0.13

^aThe Friedman test. ^bData too low to be computed. Significant value at .