Legend: variation of median VAS, OKS, and EQ-5D between baseline and twelve months follow-up has been grouped according to the grade of KOA. VAS improvement is a reduction in score plotted in green and arrow-up. All grades of OA show an improvement in pain as evidence by a reduction in the median VAS score. OKS also improved in all grades of OA with the most gains being made by those with the grade 4 group. EQ-5D improvement is an increase in score plotted in green and arrow-up, deterioration in red, and invariance in black. This shows a general trend in all severity of KOA towards improvement, but these data are not suitable for detailed subgroup analysis and statistical significance testing as grades 1 and 2 only represent 20% of the total group.
Source: Authors’ Data and reproducible statistical analysis with Open Access statistical software R (version 4.0.0 or higher).