IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury

Figure 1

IL-37-MSCs and MSCs could migrate to the injured tissue. The morphology of MSCs. (a) Passages 0, 1, 2, and 3 of MSCs. (b) FACS analysis of MSC surface marker, surface expressions of CD29, CD45, CD79a, and CD90 were detected. (c) The IL-37 and GFP proteins were detected in IL-37-MSCs and MSCs. (d) IL-37-MSC GFP-positive rate was calculated; positive rate was above 99.8% which met our needs. (e) IL-37-MSC-treated and MSC-treated intestine exhibited significant GFP fluorescence while the sham group did not, which suggested that IL-37-MSCs and MSCs could migrate to the injured tissue.

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