The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Figure 4

Strategies to tackle the effect of AGEs (88). AGEs lead to an increase in apoptosis or a decrease in proliferation via different pathways. This process can be tackled by different cellular approaches including scavenging, breaking down, or inhibiting AGEs and their precursors. RAGE can be directly blocked, or the downstream effectors can be inhibited. Oxidative stress can be reduced by antioxidants and ROS scavengers.