The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Table 4

Summary of included studies using ADSCs. Summary of the isolation procedure and sampling, AGEs concentration, application duration, and effect on outcome measurement proliferation and apoptosis.

Study name	Year	Isolation SC	AGEs application		Effect on outcome
			Concentration	Duration	Proliferation	Apoptosis
Li et al. [62]	2018	Human–adipose tissue samples enzymatically digested	100, 200, 400, 800, & 1600 μg/ml	8, 12, 24, & 48 hours		↗
Li et al. [65]	2020	Mice–adipose tissue samples enzymatically digested	20, 40, 80, & 160 μg/ml	1, 2, & 4 days	↘
Wang et al. [63]	2015	Human–adipose tissue samples enzymatically digested	50, 100, 300, & 500 μg/ml	24 hours		↗
Wang et al. [64]	2016	Human–adipose tissue samples enzymatically digested	300 μg/ml	24 hours		↗
Zhang et al. [66]	2018	Rats–adipose tissue samples enzymatically digested	40, 80, 120, & 160 μg/ml	1, 4, & 7 days	↘

SC: stem cells; ↘: decrease; ↗: increase.