The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Table 5

Summary of included studies using NSCs. Summary of the isolation procedure and sampling, AGEs concentration, application duration, and effect on outcome measurement proliferation and apoptosis.

Study name	Year	Isolation SC	AGEs application		Effect on outcome
			Concentration	Duration	Proliferation	Apoptosis
Fleitas et al. [67]	2018	Rat–brain tissue samples, outgrowth neurospheres	BDNF modified with 50 μM GO or MGO	6 days		↗
Meneghini et al. [68]	2010	Rat–brain tissue samples, outgrowth neurospheres	25, 50, 100 μg/ml	4 days	↗
Wang et al. [69]	2009	Rat–brain tissue samples, outgrowth neurospheres	0, 50, 100, 200, & 400 mg/l	3 & 7 days	↘
Wang et al. [70]	2011	Rat–brain tissue samples, outgrowth neurospheres	200 & 400 mg/l	3 days	↘

SC: stem cells; BDNF: brain-derived neurotrophic factor; GO: glyoxal; MGO: methylglyoxal; ↘: decrease; ↗: increase.