Small Extracellular Vesicles from Human Fetal Dermal Cells and Their MicroRNA Cargo: KEGG Signaling Pathways Associated with Angiogenesis and Wound Healing

<div>Effect of EVs on formation of mesh-like structures of HUVECs in vitro. (a) HUVECs in culture medium supplemented with 10 μg/ml of fetal dermal cell-derived EVs 8 hours after plating on Matrigel. (b) HUVECs in culture medium supplemented with 10 μg/ml of adult dermal cell-derived EVs 8 hours after plating. (c) HUVECs in fetal dermal cell-derived CM 3 hours after plating. (d) HUVECs in EV-depleted CM of fetal dermal cells 3 hours after plating. Negative control HUVECs in serum-free culture medium 8 hours after plating. Scale bars: 100 μm (a, c, d, e) and 50 μm (b). EV: extracellular vesicles; CM: conditioned medium; depl: depleted; neg. ctrl: negative control. The results shown are representative of four independent experiments.</div>

Stem Cells International

fig5

Figure 5

Figure 5: Small Extracellular Vesicles from Human Fetal Dermal Cells and Their MicroRNA Cargo: KEGG Signaling Pathways Associated with Angiogenesis and Wound Healing 

Figure 5 | Small Extracellular Vesicles from Human Fetal Dermal Cells and Their MicroRNA Cargo: KEGG Signaling Pathways Associated with Angiogenesis and Wound Healing 