miRNA name Role in angiogenesis/tissue regeneration References Fold increase in fetal vs. adult samples valuehsa-let-7b-5p It targets VEGF gene; validated role in angiogenesis Hua et al., 2006 [36 ]; Landskroner-Eiger et al., 2013 [34 ] 26.2091 0.0074 hsa-let-7g-5p Validated role in angiogenesis Landskroner-Eiger et al., 2013 [34 ] 175.3585 0.021 hsa-miR-10a-5p Validated role in angiogenesis; angiogenesis influencer Landskroner-Eiger et al., 2013 [34 ] 242.9505 0.03 hsa-miR-10b-3p 17.9198 0.0346 hsa-miR-15b-5p Angiogenesis regulator; delivered in regenerative medicine for cardiac repair Curtin et al., 2018 [29 ]; Wang & Olson, 2009 [39 ] 2624.268 0.0003 hsa-miR-16-5p Angiogenesis regulator; it targets VEGF gene; regulator of angiogenesis; induces tube formation of HUVECs Hua et al., 2006 [36 ]; Poliseno et al., 2006 [78 ]; Suarez & Sessa, 2009 [38 ]; Wang & Olson, 2009 [39 ] 149.6445 0.0183 hsa-miR-17-5p Angiogenesis regulator; it targets VEGF gene Caporali & Emanueli, 2011 [33 ]; Hua et al., 2006 [36 ], Wang & Olson, 2009 [39 ] 133.7475 0.0032 hsa-miR-19a-3p Validated role in angiogenesis Landskroner-Eiger et al., 2013 [34 ]; Wang & Olson, 2009 [39 ] 51.8807 0.0114 hsa-miR-19b-3p Angiogenesis regulator Caporali & Emanueli, 2011 [33 ]; Wang & Olson, 2009 [39 ] 109.3557 0.0044 hsa-miR-20a-5p It targets VEGF gene; validated role in angiogenesis Hua et al., 2006 [36 ]; Landskroner-Eiger et al., 2013 [34 ]; Wang & Olson, 2009 [39 ] 56.7629 0.0004 hsa-miR-21-5p Angiogenesis regulator; wound healing regulator Wang & Olson, 2009 [39 ]; Wang et al., 2012 [32 ] 157.6826 0.0046 hsa-miR-24-3p Highly expressed by endothelial cells Suarez & Sessa, 2009 [38 ]; Zhou et al., 2011 [40 ] 25.4984 0.0059 hsa-miR-26a-5p Proregenerative (it promotes osteogenesis-angiogenesis in mouse) Li et al., 2013 [47 ] 132.6638 0.0122 hsa-miR-26b-5p Tissue repair; remodeling in wound healing Banerjee & Sen, 2013 [31 ]; Sen et al., 2015 [30 ] 95.4933 0.0183 hsa-miR-27b-3p It targets VEGF gene; validated role in angiogenesis Hua et al., 2006 [36 ]; Landskroner-Eiger et al., 2013 [34 ]; Wang & Olson, 2009 [39 ]; Zhou et al., 2011 [40 ] 950.021 0.0096 hsa-miR-28-3p 49.9995 0.0082 hsa-miR-29b-3p Regulator of tissue regeneration; proregenerative (delivered for ECM remodeling in fibrosis treatment) Monaghan et al., 2014 [42 ]; van Rooij et al., 2008 [43 ] 61.9175 0.0105 hsa-miR-30a-3p It targets VEGF gene; endothelial cell modulator Bridge et al., 2012 [35 ]; Hua et al., 2006 [36 ] 185.51 0.0099 hsa-miR-30b-5p Angiogenesis regulator; endothelial cell modulators; it targets VEGF gene Bridge et al., 2012 [35 ]; Hua et al., 2006 [36 ] 32.3336 0.0004 hsa-miR-30c-5p Endothelial cell modulator Bridge et al., 2012 [35 ] 30.1373 0.0002 hsa-miR-30e-3p Endothelial cell modulator Bridge et al., 2012 [35 ] 41.2049 0.0041 hsa-miR-31-5p Angiogenesis regulator; wound healing Li et al., 2015 [79 ]; Wang et al., 2012 [32 ] 60.803 0.0027 hsa-miR-31-3p Angiogenesis regulator; wound healing Li et al., 2015 [79 ]; Wang et al., 2012 [32 ] 229.5474 0.0097 hsa-miR-34a-5p It targets VEGF gene 2254.5936 0 hsa-miR-92a-3p Validated role in angiogenesis Curtin et al., 2018 [29 ]; Landskroner-Eiger et al., 2013 [34 ]; Wang & Olson, 2009 [39 ] 32.781 0.0001 hsa-miR-93-3p 149.3753 0.0065 hsa-miR-99b-3p Angiogenesis promoter Kane et al., 2012 [37 ] 37.2967 0.0134 hsa-miR-99b-5p Angiogenesis promoter Kane et al., 2012 [37 ] 41.1216 0.0031 hsa-miR-103a-3p 809.2304 0.008 hsa-miR-106a-5p It targets VEGF gene; regulator of angiogenesis Hua et al., 2006 [36 ] 67.8178 0.0047 hsa-miR-106b-5p It targets VEGF gene; regulator of angiogenesis Hua et al., 2006 [36 ]; Landskroner-Eiger et al., 2013 [34 ] 56.2099 0.0084 hsa-miR-125a-5p Tube formation of HUVECs; it targets VEGF gene Hua et al., 2006 [36 ]; Poliseno et al., 2006 [78 ] 128.8981 0.0061 hsa-miR-125b-5p Angiogenesis regulator; tube formation of HUVECs Poliseno et al., 2006 [78 ]; Zhou et al., 2015 [80 ] 18.6552 0.0041 hsa-miR-127-3p 19.2386 0.0001 hsa-miR-132-3p Validated role in angiogenesis during chronic wound healing; proregenerative (it promotes angiogenesis in myocardial infarction) Landskroner-Eiger et al., 2013 [34 ]; Li et al., 2017 [81 ]; Ma et al., 2018 [44 ] 3664.7066 0.0034 hsa-miR-136-3p 164.0836 0.0268 hsa-miR-138-5p 52.6792 0.0162 hsa-miR-145-5p Angiogenesis regulator Fan et al., 2012 [82 ] 42.2841 0.0067 hsa-miR-146a-3p Wound healing (inflammatory phase) Banerjee & Sen, 2013 [31 ] 172.0832 0.0135 hsa-miR-146b-3p Wound healing (inflammatory phase); angiogenesis promoter Ahn et al., 2013 [83 ]; Banerjee & Sen, 2013 [31 ] 203.771 0.0161 hsa-miR-149-5p Scarless wound healing Lang et al., 2017 [84 ] 37.5122 0.0102 hsa-miR-151a-5p 126.8167 0.005 hsa-miR-151a-3p 17.732 0.0246 hsa-miR-152-3p 20.0452 0.0097 hsa-miR-155-5p Wound healing (inflammatory phase); amyotrophic lateral sclerosis; anti-inflammatory action; angiogenesis regulator Banerjee & Sen, 2015 [31 ]; Curtin et al., 2018 [29 ]; Suarez & Sessa, 2009 [38 ] 32.5772 0.04 hsa-miR-181a-5p Angiogenesis promoter Kane et al., 2012 [37 ] 112.4827 0.0011 hsa-miR-186-5p 78.0074 0.0165 hsa-miR-191-5p It may regulate the angiogenic actions of VEGF Landskroner-Eiger et al., 2013 [34 ] 66.0569 0.0121 hsa-miR-193a-5p It targets VEGF gene Hua et al., 2006 [36 ] 108.2673 0.0061 hsa-miR-193b-3p Proregenerative (chondrogenesis) Meng et al., 2018 [45 ] 16.6788 0.0057 hsa-miR-197-3p 47.9232 0.01 hsa-miR-199a-3p It targets VEGF gene; proregenerative (cardiac regeneration) Hua et al., 2006 [36 ]; Lesizza et al., 2017 [46 ] 79.9505 0.0112 hsa-miR-214-3p 34.8695 0.0131 hsa-miR-214-5p It targets VEGF gene Hua et al., 2006 [36 ] 493.6614 0.0151 hsa-miR-218-5p Validated role in angiogenesis Landskroner-Eiger et al., 2013 [34 ] 32.9227 0.0092 hsa-miR-221-3p Validated role in angiogenesis Landskroner-Eiger et al., 2013 [34 ] 27.5391 0.0003 hsa-miR-222-3p Angiogenesis in wound healing; validated role in angiogenesis Banerjee & Sen, 2015 [31 ]; Landskroner-Eiger et al., 2013 [34 ] 38.7974 0.0103 hsa-miR-224-5p 21.5539 0.0039 hsa-miR-320a It targets VEGF gene; validated role in angiogenesis Hua et al., 2006 [36 ]; Landskroner-Eiger et al., 2013 [34 ] 56.2268 0.0086 hsa-miR-323a-3p 686.8069 0.0163 hsa-miR-324-3p 137.7004 0.0144 hsa-miR-331-3p It targets VEGF gene Hua et al., 2006 [36 ] 43.6136 0.0043 hsa-miR-342-3p 169.8914 0.0114 hsa-miR-345-5p 200.3964 0.0134 hsa-miR-365a-3p 526.7213 0.0115 hsa-miR-370-3p 99.3169 0.0081 hsa-miR-374a-5p 44.7501 0.0225 hsa-miR-376a-3p 216.5826 0.0246 hsa-miR-376c-3p 216.5826 0.0246 hsa-miR-382-5p 6102.4887 0.0009 hsa-miR-409-3p 173.9373 0.0097 hsa-miR-411-5p 99.6678 0.0353 hsa-miR-424-3p 482.6326 0.0137 hsa-miR-432-5p 125.5471 0.0385 hsa-miR-433-3p 778.7489 0.0057 hsa-miR-455-5p 611.2326 0.0122 hsa-miR-484 85.625 0.0066 hsa-miR-487b-3p 131.5413 0.0028 hsa-miR-493-3p 1303.6278 0.0053 hsa-miR-532-3p 42.572 0.0015 hsa-miR-532-5p Angiogenesis Slater et al., 2018 [85 ] 1363.2918 0.0072 hsa-miR-539-5p 350.9595 0.0063 hsa-miR-574-3p 59.5134 0.0121 hsa-miR-625-3p 77.7476 0.002 hsa-miR-708-5p 59.2604 0.0013 hsa-miR-766-3p 1533.4818 0.016 hsa-miR-886-5p 75.0277 0.0048 hsa-miR-1290 24.3418 0.0021