KEGG signaling pathway Role in angiogenesis/wound healing References log10 ( Adherens junction Wound closure Fenteany et al., 2000 [47 ] HIPPO Organ regeneration Juan & Hong, 2016 [48 ]; Lee et al., 2014 [49 ]; Zhao et al., 2011 [51 ]; Wang et al., 2017 [50 ] p53 Promotes VEGF expression and angiogenesis Farhang Ghahremani et al., 2013 [52 ] TGF-beta Skin wound healing Finnson et al., 2013 [53 ]; Ramirez et al., 2014 [54 ] ECM-receptor interaction Wound repair Olczyk et al., 2014 [55 ] Focal adhesion Cell migration; angiogenesis Zhao & Guan, 2011 [56 ] 0.000175201 mTOR Interconnected to PI3K-Akt pathway to accelerate epithelial wound healing; angiogenesis Castilho et al., 2013 [56 ]; Karar & Maity, 2011 [59 ] 0.000176029 HIF-1 Accelerating wound healing by enhancing angiogenesis Hong et al., 2014 [60 ] 0.000538735 ErbB Mediates proliferation and migration of keratinocytes in wound healing (ErbB1) Pastore et al., 2008 [61 ] 0.001490837 FoxO Upstream in the activation of both TGF-beta and PI3K-Akt signaling pathways 0.002880647 Wnt Participates to each stage of the healing process Whyte et al., 2012 [62 ] 0.00326995 Notch Angiogenesis and endothelial cell formation; essential in organ regeneration; vasculature repair after brain trauma and wound healing Carlson et al., 2007 [63 ]; Raya et al., 2003 [66 ]; Ran et al., 2015 [65 ]; Chigurupati et al., 2007 [64 ] 0.004876559 Neurotrophin Novel regulator of angiogenesis Kraemer & Hempstead, 2003 [67 ] 0.009582793 MAPK Skin reepithelialization Deng et al., 2006 [68 ] 0.008652606 Insulin Upstream to PI3k/Akt and mTOR Karar & Maity, 2011 [59 ] 0.014139516
