Small Extracellular Vesicles from Human Fetal Dermal Cells and Their MicroRNA Cargo: KEGG Signaling Pathways Associated with Angiogenesis and Wound Healing

Table 4

Customized ProcartaPlex human growth factor and chemokine panel. Amount of soluble factors in EV-depleted vs. whole CM of fetal dermal cells.

Soluble factor	Role in MSC-mediated wound healing	EV-depleted CM (pg/ml/10^6 cells/24 h)	Whole CM (pg/ml/10^6 cells/24 h)
VEGF-A	Angiogenesis [86]
HGF	Epithelialization, neovascularization [87]
SDF-1 alpha (CXCL-12)	Angiogenesis [88]; cell migration [89]
MCP-1 (CCL-2)	Angiogenesis [1]; recruitment of neutrophils [90]; remodeling [91]
IL-8	Recruitment of neutrophils, epidermal cell migration, angiogenesis [91]
GRO-alpha (CXCL-1)	Recruitment of neutrophils [91]; angiogenesis [1]

Plotted values () represent EV-depleted CM () compared to whole CM (). Differences not denoted with an asterisk are not significant. EV: extracellular vesicle; CM: conditioned medium.