Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors

Figure 2

BMMSC inhibit the proliferation of CML cells in vitro. (a) Cell proliferation of K562 cells and PCML cells cocultured with or without different MSC. (b) K562 and PCML cells were cocultured with hBMMSC at different ratios (1 : 1, 5 : 1, and 10 : 1) for 48 h. Then, the proliferation of K562 cells and PCML cells was evaluated. The data were expressed as the of three independent experiments. Student’s -test.

(a)

(b)