Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors

Figure 5

hBMMSC-Exo induce drug resistance in CML cells. (a) The proliferation of K562 and PCML cells after imatinib treatment (1 μM) in the presence of different concentrations of hBMMSC-Exo (0, 50, 100, 150, and 200 μg/mL) for 24, 48, and 72 h. (b) The apoptosis of K562 and PCML cells after imatinib treatment (1 μM) in the presence of different concentrations of MSC-Exo (0, 50, 100, 150, and 200 μg/mL) for 48 h. (c) Representative blots and densitometry analysis of Caspase3, Bax, Bcl-2, and GAPDH in K562 cells after imatinib treatment (1 μM) in the presence of different concentrations of hBMMSC-Exo (0, 50, 100, 150, and 200 μg/mL) for 48 h. The data were expressed as the of three independent experiments. Student’s -test.

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