Study Country Study type Animal models Age and weight No. of rats Osteoporosis model Experimental group Injection dose Control group Detection time Detection sites Outcome measures Uejima et al. (2008) Japan Non-RCT SD, female, rats 12 w 10/10 OVX BMSCs Sham-operation+saline 8 w Femur (1) Yang et al. (2013) China RCT SD, female, rats 10/10/10 OVX BMSCs OVX control, sham-operation 12 w Femur, lumbar vertebrae (1) Shuai et al. (2014) China RCT SD, female, rats 140-150 g 4/4/4 OVX BMSCs OVX control, sham-operation+PBS 10 w Femur (1), (3) Lei et al. (2016) China RCT Wistar, female, rats 210-255 g 15/15/45 OVX AM-MSCs+zoledronic acid NP OVX control, sham-operation 13 w Femur (1) Li et al. (2016) China RCT SD, female, rats 7 w, 180-220 g 10/10/10 OVX ADSCs OVX control, sham-operation+PBS 6 w Femur (1), (2) Chen et al. (2017) China RCT SD, female, rats 7 w, 180-220 g 10/10/10 OVX BMSCs OVX control, sham-operation+PBS 2 w Femur, lumbar vertebrae (1), (2), (3) Duan et al. (2017) China RCT SD, female, rats 10 w, 18/10 OVX BMSCs OVX control, sham-operation 8 w Tibia (2), (3) Hong et al. (2018) South Korea RCT SD, female, rats 12 w 10/10/10 OVX hUCB-MSCs OVX control, sham-operation 4 w Femur (3) Tang et al. (2018) China RCT SD, female, rats 3 m, 10/10/10 OVX ADSCs+icariin NP OVX control, sham-operation 12 w Femur, lumbar vertebrae (1) Uri et al. (2018) Israel RCT SD, female, rats 5 m, 15/15 OVX ADSCs NP OVX control NP Femur (3) Xue et al. (2019) China RCT SD, female, rats 30/10/10 OVX BMSCs OVX control, sham-operation 4 w, 8 w Tibia (1) Sadat-Ali et al. (2019) Saudi Arabia Non-RCT SD, female, rats NP 10/10 OVX BMSCs OVX control+saline 8 w Femur (2), (3) Aglan et al. (2020) Egypt Non-RCT Wistar, female, rats 130-150 g 30/10/10 OVX BMSCs+nano-HA OVX control, sham-operation 2 m Femur (1)
