Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds

Table 1

Gene therapy for natural healing of the tendon.

Genes	Delivery method	Function	Reference
Tnmd	Transfection	Major constituents of collagen fiber. Positively regulated by Scx	[47]
Scx	Polymersome scaffolding material	Major marker of tendon & ligament tissues. Encode protein which expressed during embryonic development	[13]
Fmod	Carried by fibrin gel	Positively regulate expression of TGF-β. Encode protein which play role in ECM deposition	[47]
COL-I	Transfection	Major constituents of ECM	[162]
COL-III	Transfection	Major constituents of ECM	[162]
COL-V	Transfection	Constituent of ECM and play role in fiber strength	[163]
LAMA-4	Fibrin-heparin-based delivery	Encodes laminin alpha-4, noncollagenous constituent of ECM	[164]
ELN	Liposomal nanoparticles	Encodes elastin protein, major structural constituent of ECM	[164]
FBN-II	Carried by fibrin gel	Encodes fibrillin-II protein, major structural constituent of ECM	[164]
Comp	Nanoliposomes	Belongs to the ECM protein. Structural role	[165]
Decorin	PLGA-NP	Constituent of ECM structural protein, positively regulated by TGF-β, and enhance strength and organization of collagen fibers	[160]

Abbreviations: Tnmd: tenomodulin; Scx: scleraxis; Fmod: fibromodulin; COL-I: collagen-I; LAMA-4: laminin subunit alpha-4; ELN: elastin gene; FBN-II: fibrillin-II; Comp: cartilage oligomeric matric protein.