Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21

<div>hUCMSC-EVs promoted the proliferation of Schwann cells <i>in vitro</i>. (a) CM-Dil-labeled hUCMSC-EVs are internalized by RSC96 cells, scale bar: 20 <i>μ</i>m. (b) The proliferation activity of RSC96 cells by CCK-8 assay. (c, d) The proliferating ability of RSC96 cells by colony-forming assay. 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(e) Western blot analysis of the protein expression of p-PI3K, PI3K, p-AKT, and AKT in Schwann cells.</div>

Stem Cells International

fig4

Figure 4

Figure 4: Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21 

Figure 4 | Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21 