Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21

<div>miR-21 is critical for hUCMSC-EV-mediated proliferation of Schwann cells. (a, b) RT-PCR analysis of relative expression of miR-21 in RSC96 cells treated with hUCMSC-EVs or miR-21 inhibitor-EVs. (c–e) The effects of miR-21 inhibitor-EVs on RSC96 cell proliferation as determined by CCK-8 assay and colony-forming assay, respectively. (f) The effects of the protein expression of p-PI3K, PI3K, p-AKT, and AKT in RSC96 cells treated with miR-21 inhibitor-EVs or inhibitor NC-EVs. (g, h) The expression intensity of S100 in regenerated nerve tissue after injection of miR-21 inhibitor-EVs or inhibitor NC-EVs. 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Stem Cells International

fig5

Figure 5

Figure 5: Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21 

Figure 5 | Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote the Proliferation of Schwann Cells by Regulating the PI3K/AKT Signaling Pathway via Transferring miR-21 