Stem Cells International

Review Article

The Clinical Trials of Mesenchymal Stromal Cells Therapy

Table 1

Completed clinical trials on mesenchymal stromal cell-based therapy during 2016-2020 (U. S. National Library of Medicine).
Organ systemDisease/syndromePhaseDateCountrySourceTransplantationCT code
CardiovascularCardiomyopathy12019United StatesNDAllotransplantNCT02509156
CardiovascularGraft versus host disease1 and 22016PakistanBone marrowAllotransplantNCT02824653
CardiovascularIschemic cardiomyopathy22020United StatesBone marrowAutotransplantNCT02501811
GastrointestinalCirrhosis42020IndiaBone marrowAutotransplantNCT04243681
GastrointestinalXerostomia22017DenmarkAdipose tissueAutotransplantNCT02513238
GastrointestinalType 2 diabetes mellitus1 and 22019VietnamBone marrowAutotransplantNCT03343782
ImmuneDiscordant immunological response in HIV1 and 22019SpainAdipose tissueAllotransplantNCT02290041
ImmuneSystemic lupus erythematosus12018United StatesUmbilical cordAllotransplantNCT03171194
IntegumentaryAtopic dermatitis12017KoreaNDAutotransplantNCT02888704
IntegumentaryCaesarean section scars22018ChinaUmbilical cordAllotransplantNCT02772289
IntegumentaryChronic ulcer12020IndonesiaConditioned medium
Wharton’s jelly		AllotransplantNCT04134676
IntegumentaryChronic venous ulcer1 and 22020GermanySkinAllotransplantNCT03257098
IntegumentaryDiabetic foot ulcer22016KoreaAdipose tissueAllotransplantNCT02619877
IntegumentaryDiabetic neuropathic ulcer1 and 22020GermanySkinAllotransplantNCT03267784
IntegumentaryGingival recession1 and 22019BelarusAdipose tissueAutotransplantNCT04434794
IntegumentaryPerianal fistula12019United StatesNDAutotransplantNCT02589119
IntegumentaryRecessive dystrophic epidermolysis bullosa1 and 22020KoreaUmbilical cordAllotransplantNCT04520022
IntegumentaryRectovaginal fistula12019RussiaAdipose tissueAutotransplantNCT03643614
IntegumentarySkin scar1 and 22019PolandAdipose tissueAutotransplantNCT03887208
IntegumentarySkin wound12019PakistanUmbilical cordAllotransplantNCT04219657
IntegumentarySurgical leak fistula12019United StatesAdipose tissueAutotransplantNCT02807389
IntegumentaryUltrafiltration failure1 and 22017IranAdipose tissueAllotransplantNCT02801890
NervousAlzheimer’s disease1 and22019United StatesAdipose tissueAutotransplantNCT03117738
NervousBrain death12020IndiaNDNDNCT02742857
NervousCerebral infarction1 and 22017KoreaUmbilical cordAllotransplantNCT02378974
NervousCorneal ulcer
Corneal disease
Corneal dystrophy		1&22019BelarusAdipose tissueAutotransplantNCT04484402
NervousMotor neuron disease12016BrazilNDAutotransplantNCT02987413
NervousMultiple sclerosis22019CanadaNDAutotransplantNCT02239393
NervousMultiple sclerosis1 and 22020JordanUmbilical cordAllotransplantNCT03326505
NervousMultiple sclerosis22018IsraelBone marrowAutotransplantNCT02166021
NervousMultiple sclerosis1 and22017SpainBone marrowAutotransplantNCT02495766
NervousOcular corneal burn22017ChinaBone marrowNDNCT02325843
NervousParkinson’s disease12019United StatesBone marrowAutotransplantNCT02611167
NervousRefractory epilepsy12019RussiaAdipose tissueAutotransplantNCT03676569
NervousRetinitis pigmentosa32019TurkeyWharton’s jellyAllotransplantNCT04224207
NervousSpinal cord injuries1 and 22018JordanBone marrow
Adipose tissue		AutotransplantNCT02981576
NervousSpinal cord injuries1 and 22020ChinaUmbilical cordAllotransplantNCT02481440
NervousSpinal cord injuries22017SpainBone marrowAutotransplantNCT02570932
NervousSpinal cord injury1 and 22019SpainWharton’s jellyAllotransplantNCT03003364
ReproductiveAtrophic endometrium22019RussiaBone marrowAutotransplantNCT03166189
ReproductiveErectile dysfunction12018KoreaBone marrowAutotransplantNCT02344849
ReproductiveErectile dysfunction12018JordanWharton’s jellyAllotransplantNCT02945449
ReproductiveErectile dysfunction1 and 22019JordanWharton’s jellyAllotransplantNCT03751735
ReproductiveFistula vagina12020United StatesNDAutotransplantNCT03220243
ReproductiveOvarian cancer12019United StatesNDAutotransplantNCT02530047
ReproductivePremature ovarian failure1 and 22018ChinaUmbilical cordAllotransplantNCT02644447
RespiratoryAcute respiratory distress syndrome12019United StatesBone marrowAllotransplantNCT02804945
RespiratoryBronchopulmonary dysplasia1 and 22016United StatesUmbilical cordAllotransplantNCT02381366
RespiratoryCOVID-19
Acute respiratory distress syndrome		1 and 22020United StatesUmbilical cordAllotransplantNCT04355728
RespiratoryCOVID-19
Prophylaxis		12020United StatesUmbilical cordAllotransplantNCT04573270
RespiratoryCOVID-1922020ChinaUmbilical cordAllotransplantNCT04288102
RespiratoryCOVID-1912020ChinaExosome
Adipose tissue		AllotransplantNCT04276987
RespiratoryLaryngotracheal stenosis1 and 22019BelarusOlfactory mucosaAutotransplantNCT03130374
RespiratoryNoncystic fibrosis bronchiectasis12019United StatesBone marrowAllotransplantNCT02625246
RespiratoryPneumoconiosis12019ChinaUmbilical cordAllotransplantNCT02668068
SkeletalBone fracture1 and 22020IndiaAdipose tissueAutotransplantNCT04340284
SkeletalDental implant therapy1 and 22017GreeceBone marrowAutotransplantNCT03070275
SkeletalKnee osteoarthritis22018United StatesBone marrowAutotransplantNCT02958267
SkeletalKnee osteoarthritis1 and 22018CanadaBone marrowAutotransplantNCT02351011
SkeletalKnee osteoarthritis22018United StatesAdipose tissueAutotransplantNCT02674399
SkeletalOsteoarthritis12018ChinaAdipose tissueAllotransplantNCT02641860
SkeletalOsteonecrosis1 and 22018SpainBone marrowAutotransplantNCT01605383
SkeletalOsteoporosis
Spinal fractures		12016SpainBone marrowAutotransplantNCT02566655
SkeletalRheumatoid arthritis12018IranBone marrowAutotransplantNCT03333681
SkeletalRheumatoid arthritis1 and 22020United StatesAdipose tissueAutotransplantNCT03691909
UrinaryStress urinary incontinence1 and 22019BelarusAdipose tissueAutotransplantNCT04446884
UrinaryStress urinary incontinence32016EgyptBone marrowAutotransplantNCT02334878
ND: no data.