Review Article

The Clinical Trials of Mesenchymal Stromal Cells Therapy

Table 3

Recruiting clinical trials on mesenchymal stromal/stem cell-based therapy started during 2016-2020 (U. S. National Library of Medicine).

Organ systemDisease/syndromePhaseDateCountrySourceTransplantationCT code

CardiovascularAbdominal aortic aneurysm12016United StatesNDAllotransplantNCT02846883
CardiovascularAcute myocardial infarction1 and 22019IndonesiaUmbilical cordAllotransplantNCT04340609
CardiovascularAcute myocardial infarction12019TaiwanUmbilical cordAllotransplantNCT04056819
CardiovascularCardiomyopathy12020United StatesBone marrowAllotransplantNCT02962661
CardiovascularCerebrovascular disorders1 and 22019IranExosomeAllotransplantNCT03384433
CardiovascularCritical limb ischemia12020KoreaAdipose tissueAllotransplantNCT04661644
CardiovascularCritical limb ischemia22020FranceAdipose tissueAutotransplantNCT03968198
CardiovascularDiabetic foot ulcer32020KoreaAdipose tissueAllotransplantNCT04569409
CardiovascularDiabetic foot ulcer12020ChinaUmbilical cordAllotransplantNCT04464213
CardiovascularHeart defects1 and 22017United StatesNDAllotransplantNCT03079401
CardiovascularHeart failure12016United StatesBone marrowAllotransplantNCT02408432
CardiovascularHeart failure2 and 32018PolandWharton’s jellyAllotransplantNCT03418233
CardiovascularIschemia12017United StatesBone marrowAllotransplantNCT02685098
CardiovascularIschemia reperfusion injury22020United StatesAdipose tissueAllotransplantNCT04388761
CardiovascularIschemic heart disease1 and 22018ChinaBone marrowAutotransplantNCT03397095
CardiovascularIschemic stroke12020TaiwanUmbilical cordAllotransplantNCT04434768
CardiovascularIschemic stroke12019TaiwanUmbilical cordAllotransplantNCT04097652
CardiovascularMyocardial infarction12019SpainUmbilical cordAllotransplantNCT03798353
CardiovascularMyocardial infarction2 and 32017PolandWharton’s jellyAllotransplantNCT03404063
CardiovascularMyocardial ischemia22016FranceBone marrowAutotransplantNCT02462330
DigestiveCrohn colitis1 and 22020United StatesBone marrowAllotransplantNCT04548583
DigestiveCrohn disease12018United StatesNDAutotransplantNCT03449069
DigestiveCrohn disease1 and 22018BelgiumNDNDNCT03901235
DigestiveFistula1 and 22020United StatesBone marrowAllotransplantNCT04519671
DigestiveFistula1 and 22020United StatesBone marrowAllotransplantNCT04519684
DigestiveHepatitis B12018ChinaUmbilical cordAllotransplantNCT03826433
DigestiveLiver cirrhosis1 and 22018SingaporeBone marrowAutotransplantNCT03626090
DigestiveLiver cirrhosis22019ChinaUmbilical cordAllotransplantNCT03945487
DigestiveLiver cirrhosis1 and 22018IndonesiaUmbilical cordAllotransplantNCT04357600
DigestiveLiver failure1 and 22019GermanySkinAllotransplantNCT03860155
DigestiveLiver transplantation12017GermanyBone marrowAllotransplantNCT02957552
DigestivePrimary biliary cirrhosis1 and 22019VietnamUmbilical cordAllotransplantNCT04522869
DigestiveRectovaginal fistula1 and 22020United StatesBone marrowAllotransplantNCT04519697
DigestiveUlcerative colitis1 and 22018ChinaAdipose tissueAllotransplantNCT03609905
DigestiveUlcerative colitis12020United StatesAdipose tissueAutotransplantNCT04312113
DigestiveUlcerative colitis1 and 22020United StatesBone marrowAllotransplantNCT04543994
EndocrineDiabetic kidney disease12019United StatesAdipose tissueAutotransplantNCT03840343
EndocrineType 1 diabetes12017JordanAdipose tissueAllotransplantNCT02940418
EndocrineType 1 diabetes1 and 22019SwedenWharton’s jellyAllotransplantNCT03973827
EndocrineType 2 diabetes1 and 22016IndonesiaBone marrow
Umbilical cord
Autotransplant
Allotransplant
NCT04501341
EndocrineType 2 diabetes1 and 22020ChinaUmbilical cordAllotransplantNCT04441658
ImmuneAcute graft versus host disease1 and 22019MalaysiaUmbilical cordAllotransplantNCT03847844
ImmuneDiabetic foot ulcer12019United StatesUmbilical cordAllotransplantNCT04104451
ImmuneDrug resistant1 and 22020ChinaAdipose tissueAllotransplantNCT04544215
ImmuneKeratoconjunctivitis sicca22020DenmarkAdipose tissueAllotransplantNCT04615455
ImmuneLupus erythematosus1 and 22019BelarusOlfactory mucosaAllotransplantNCT04184258
ImmuneLymphoblastic leukemia22017United StatesUmbilical cordAutotransplantNCT03096782
ImmunePrimary sclerosing cholangitis
Autoimmune hepatitis
1 and 22018United KingdomUmbilical cordAllotransplantNCT02997878
ImmuneRenal lupus22019ChileUmbilical cordAllotransplantNCT03917797
ImmuneType 1 diabetes12020United StatesUmbilical cordAllotransplantNCT04061746
ImmuneType 1 diabetes1 and 22017SwedenWharton’s jellyAllotransplantNCT03406585
IntegumentaryCaesarean section scars22020ChinaPerinatal tissueAllotransplantNCT04034615
IntegumentaryPsoriasis1 and 22019ChinaAdipose tissueAllotransplantNCT03392311
IntegumentaryWound12019ChinaND
Conditioned medium
NDNCT04235296
NervousAlzheimer’s disease1 and 22020ChinaAdipose tissueAllotransplantNCT04388982
NervousAlzheimer’s disease12019United StatesUmbilical cordAllotransplantNCT04040348
NervousAmyotrophic lateral sclerosis22017United StatesAdipose tissueAutotransplantNCT03268603
NervousAmyotrophic lateral sclerosis1 and 22020PolandWharton’s jellyAllotransplantNCT04651855
NervousCerebral palsy1 and 22020IndonesiaUmbilical cordAllotransplantNCT04314687
NervousCornea12020United StatesBone marrowAllotransplantNCT04626583
NervousDry eye1 and 22020ChinaUmbilical cord
Exosome
AllotransplantNCT04213248
NervousNonarteritic anterior ischemic optic neuropathy22018SpainBone marrowAllotransplantNCT03173638
NervousParkinson’s disease1 and 22018JordanUmbilical cordAllotransplantNCT03684122
NervousParkinson’s disease22020United StatesBone marrowAllotransplantNCT04506073
NervousRecurrent glioblastoma12019United StatesBone marrowAllotransplantNCT03896568
NervousSclerosis12016JordanBone marrowAutotransplantNCT03069170
NervousSpinal cord injuries1 and 22016SpainAdipose tissueAllotransplantNCT02917291
NervousSpinal cord injuries22020United StatesAdipose tissueAutotransplantNCT04520373
NervousSpinal cord injuries12017JordanBone marrowAutotransplantNCT04288934
NervousSpinal cord injuries22019ChinaUmbilical cordAllotransplantNCT03521336
NervousSpinal cord injuries22019ChinaUmbilical cordAllotransplantNCT03521323
NervousSpinal cord injuries22019ChinaUmbilical cordAllotransplantNCT03505034
NervousStroke1 and 22020NetherlandsBone marrowAllotransplantNCT03356821
NervousTraumatic brain injury1 and 22020United StatesAdipose tissueAutotransplantNCT04063215
ReproductiveErectile dysfunction22020KoreaBone marrowAutotransplantNCT04594850
ReproductiveIntraventricular hemorrhage22017KoreaUmbilical cordAllotransplantNCT02890953
ReproductiveUterine scar12020ChinaUmbilical cordAllotransplantNCT03181087
ReproductiveUterine scar22020ChinaUmbilical cordAllotransplantNCT02968459
ReproductiveUterus injury22020ChinaUmbilical cordAllotransplantNCT03386708
RespiratoryAcute respiratory distress syndrome1 and 22019SpainAdipose tissueAllotransplantNCT04289194
RespiratoryAcute respiratory distress syndrome22019United StatesBone marrowAllotransplantNCT03818854
RespiratoryAcute respiratory distress syndrome1 and 22020United StatesNDAllotransplantNCT04524962
RespiratoryAcute respiratory distress syndrome1 and 22019United KingdomUmbilical cordAllotransplantNCT03042143
RespiratoryAdenocarcinoma of lung1 and 22019United KingdomNDAllotransplantNCT03298763
RespiratoryBronchopulmonary dysplasia12019United StatesBone marrow
Exosome
AllotransplantNCT03857841
RespiratoryBronchopulmonary dysplasia12019SpainNDNDNCT02443961
RespiratoryBronchopulmonary dysplasia1 and 22019ChinaUmbilical cordAllotransplantNCT03645525
RespiratoryBronchopulmonary dysplasia12018ChinaUmbilical cordAllotransplantNCT03873506
RespiratoryBronchopulmonary dysplasia1 and 22019ChinaUmbilical cordAllotransplantNCT03774537
RespiratoryBronchopulmonary dysplasia12018ChinaUmbilical cordAllotransplantNCT03558334
RespiratoryBronchopulmonary dysplasia22018KoreaUmbilical cordAllotransplantNCT03392467
RespiratoryBronchopulmonary dysplasia22019KoreaUmbilical cordAllotransplantNCT04003857
RespiratoryBronchopulmonary dysplasia12018TaiwanUmbilical cordAllotransplantNCT03631420
RespiratoryBronchopulmonary dysplasia12019VietnamUmbilical cordAllotransplantNCT04062136
RespiratoryChronic lung allograft dysfunction22017AustraliaBone marrowAllotransplantNCT02709343
RespiratoryChronic obstructive pulmonary disease12020United StatesNDNDNCT04047810
RespiratoryChronic obstructive pulmonary disease1 and 22020VietnamUmbilical cordAllotransplantNCT04433104
RespiratoryChronic obstructive pulmonary disease12020TaiwanUmbilical cordAllotransplantNCT04206007
RespiratoryCOVID-1912020MexicoAdipose tissueAllotransplantNCT04611256
RespiratoryCOVID-191 and 22020BelgiumBone marrowAllotransplantNCT04445454
RespiratoryCOVID-1912020CanadaBone marrowAllotransplantNCT04400032
RespiratoryCOVID-1922020PakistanBone marrowAllotransplantNCT04444271
RespiratoryCOVID-1922020SpainBone marrowAllotransplantNCT04361942
RespiratoryCOVID-1912020SwedenBone marrowAllotransplantNCT04447833
RespiratoryCOVID-1912020United StatesBone marrowAllotransplantNCT04397796
RespiratoryCOVID-1932020United StatesBone marrowAllotransplantNCT04371393
RespiratoryCOVID-1912020United StatesBone marrowAllotransplantNCT04629105
RespiratoryCOVID-1912020United StatesCord bloodAllotransplantNCT04565665
RespiratoryCOVID-191 and 22020United StatesWharton’s jellyAllotransplantNCT04399889
RespiratoryCOVID-191 and 22020ChinaDental pulpAllotransplantNCT04336254
RespiratoryCOVID-1912020IndonesiaNDAllotransplantNCT04535856
RespiratoryCOVID-1922020MexicoNDAllotransplantNCT04416139
RespiratoryCOVID-1922020SpainNDAllotransplantNCT04615429
RespiratoryCOVID-1922020United StatesNDAllotransplantNCT04466098
RespiratoryCOVID-1912020BrazilNDAllotransplantNCT04525378
RespiratoryCOVID-192 and 32020IranND
Exosome
NDNCT04366063
RespiratoryCOVID-191 and 22020United StatesNDAllotransplantNCT04524962
RespiratoryCOVID-191 and 22020UkraineUmbilical cordAllotransplantNCT04461925
RespiratoryCOVID-1922020Germany
Israel
Umbilical cordAllotransplantNCT04614025
RespiratoryCOVID-1922020United StatesUmbilical cordAllotransplantNCT04389450
RespiratoryCOVID-191 and 22020ChinaUmbilical cordAllotransplantNCT04339660
RespiratoryCOVID-1912020IndonesiaUmbilical cordAllotransplantNCT04457609
RespiratoryCOVID-1922020SpainUmbilical cordAllotransplantNCT04366271
RespiratoryCOVID-191 and 22020United StatesUmbilical cordAllotransplantNCT04494386
RespiratoryCOVID-1922020PakistanUmbilical cordAllotransplantNCT04437823
RespiratoryCOVID-1912020ChinaUmbilical cordAllotransplantNCT04252118
RespiratoryCOVID-191 and 22020TurkeyUmbilical cordAllotransplantNCT04392778
RespiratoryCOVID-1912020JordanWharton’s jellyAllotransplantNCT04313322
RespiratoryCOVID-191 and 22020SpainWharton’s jellyAllotransplantNCT04390139
RespiratoryHealthy12020ChinaAdipose tissue exosomeAllotransplantNCT04313647
RespiratoryHoarseness1 and 22020SwedenBone marrowAutotransplantNCT04290182
RespiratoryLung disease12019United StatesBone marrowAllotransplantNCT03929120
RespiratoryPneumonia22020ChinaUmbilical cordAllotransplantNCT04269525
RespiratoryPulmonary hypertension1 and 22019ChinaAdipose tissueAutotransplantNCT04055415
SkeletalAlveolar bone atrophy32020SpainBone marrowAutotransplantNCT04297813
SkeletalAneurysmal bone cyst1 and 22018JordanBone marrowAutotransplantNCT03066245
SkeletalCartilage defect12018United StatesAdipose tissueAutotransplant
Allotransplant
NCT03672825
SkeletalDisc disease22017IndonesiaBone marrowAllotransplantNCT04499105
SkeletalDisc disease12019ChinaUmbilical cordAllotransplantNCT04104412
SkeletalKnee cartilage injury1 and 22018ChinaAdipose tissueAutotransplantNCT03955497
SkeletalKnee osteoarthritis22020ChinaAdipose tissueAllotransplantNCT04208646
SkeletalKnee osteoarthritis1 and 22019TaiwanAdipose tissueAllotransplantNCT03943576
SkeletalKnee osteoarthritis1 and 22019PolandAdipose tissueAutotransplantNCT03869229
SkeletalKnee osteoarthritis12017JordanAdipose tissueAutotransplantNCT02966951
SkeletalKnee osteoarthritis1 and 22020UkraineBone marrowAllotransplantNCT04453111
SkeletalKnee osteoarthritis1 and 22019KoreaBone marrowAllotransplantNCT04240873
SkeletalKnee osteoarthritis12018United StatesBone marrowAutotransplantNCT03477942
SkeletalKnee osteoarthritis12019ChileUmbilical cordAllotransplantNCT03810521
SkeletalKnee osteoarthritis12019KoreaUmbilical cordAllotransplantNCT04037345
SkeletalKnee osteoarthritis12020KoreaUmbilical cordAllotransplantNCT04339504
SkeletalKnee osteoarthritis12017JordanWharton’s jellyAllotransplantNCT02963727
SkeletalLow back pain12020United StatesBone marrowAllotransplantNCT04410731
SkeletalMeniscus injuries22019United StatesAdipose tissueAutotransplantNCT04274543
SkeletalNonunion fracture32017France
Germany
Bone marrowAutotransplantNCT03325504
SkeletalOsteoarthritis22016FranceAdipose tissueAutotransplantNCT02838069
SkeletalOsteoarthritis12016United StatesAdipose tissueAutotransplantNCT02805855
SkeletalOsteoarthritis12018United StatesAdipose tissueAutotransplantNCT03608579
SkeletalOsteoarthritis32019United StatesBone marrow
Adipose tissue
AutotransplantNCT03818737
SkeletalOsteoarthritis22020ChinaUmbilical cordAllotransplantNCT03383081
SkeletalOsteoarthritis1 and 22020IndonesiaUmbilical cordAllotransplantNCT04314661
SkeletalOsteoarthritis1 and 22019PolandWharton’s jellyAllotransplantNCT03866330
SkeletalOsteochondral fracture of talus32019ChileUmbilical cordAllotransplantNCT03905824
SkeletalOsteogenesis imperfecta1 and 22019SwedenFetal liverAllotransplantNCT03706482
SkeletalOsteoporosis22020IndonesiaUmbilical cordAllotransplantNCT04501354
SkeletalRheumatoid arthritis12017United StatesNDAllotransplantNCT03186417
SkeletalRheumatoid arthritis1 and 22018KoreaUmbilical cordAllotransplantNCT03618784
SkeletalRotator cuff tear22020BrazilNDNDNCT03362424
SkeletalSpinal tuberculosis22017IndonesiaNDNDNCT04493918
UrinaryCOVID-191 and 22020United StatesBone marrowAllotransplantNCT04445220
UrinaryKidney diseases1 and 22019BangladeshAdipose tissueAutotransplantNCT03939741
UrinaryKidney diseases1 and 22017Ireland
Italy
United Kingdom
Bone marrowAllotransplantNCT02585622
UrinaryNephropathy12020JapanAdipose tissueAllotransplantNCT04342325
UrinaryPelvic radiation22019FranceNDNDNCT02814864
UrinaryRenal12020United StatesAdipose tissueAllotransplantNCT04392206
UrinaryRenal transplantation12018United StatesNDAllotransplantNCT03504241
UrinaryRenal transplantation22016United StatesNDAutotransplantNCT03478215
UrinaryType 2 diabetes1 and 22020ChinaUmbilical cordAllotransplantNCT04216849

ND: no data.