Review Article
The Clinical Trials of Mesenchymal Stromal Cells Therapy
Table 4
Diseases can be tested clinically for treatment with mesenchymal stromal/stem cells in human based on the successful in vivo model studies.
| Organ system | Disease/syndrome | Source | Transplantation | References |
| Cardiovascular | Myelodysplastic syndromes | Bone marrow | Allotransplant | [114] | Gastrointestinal | Hepatic failure | Bone marrow | Allotransplant | [115] | Nervous | Epilepticus | Exosome | Allotransplant | [117] | Nervous | Glioblastoma | Bone marrow | Allotransplant | [118] | Nervous | Glioblastoma | Adipose tissue | Allotransplant | [119] | Nervous | Hypoxic-ischemic encephalopathy | Umbilical cord | Allotransplant | [120] | Nervous | Loss of retinal ganglion cells | Bone marrow-derived exosomes | Allotransplant | [121] | Nervous | Nerve regeneration | Bone marrow | Allotransplant | [122] | Reproductive | Azoospermia | Adipose tissue | Allotransplant | [123] | Reproductive | Azoospermia | Bone marrow | Allotransplant | [124] | Reproductive | Mammary adenocarcinoma | Adipose tissue | Allotransplant | [116] | Skeletal | Bone formation | ND | Allotransplant | [125] | Skeletal | Calvarial defects | Bone marrow Adipose tissue | Allotransplant | [126] | Skeletal | Periodontal defects | Exosome | Allotransplant | [127] | Urinary | Focal segmental glomerulosclerosis | Bone marrow | Allotransplant | [128] | Urinary | Nephron generation in kidney cortices | ND | Allotransplant | [129] |
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ND: no data.
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