Intervertebral Disc Stem/Progenitor Cells: A Promising “Seed” for Intervertebral Disc Regeneration

Table 1

Identification and surface markers of IVDSPCs.

Species	Cell type	Surface markers	References
Human	NPSPCs	CD73+, CD90+, CD105+, CD29-CD45-	Qi et al., 2019 [115]
Human	NPSPCs	CD73+, CD90+, CD105+, CD34-, CD45-, HLA-DR-	Liu et al., 2017 [71]
Human	NPSPCs	CD73+, CD90+, CD105+, CD34-, CD45-	Chen et al., 2016 [116]
Human	NPSPCs	Tie2+, GD2+, Flt1+, CD271+, CD24-	Sakai et al., 2012 [23]
Human	NPSPCs	CD90+, CD73+, CD105+, CD106+, CD166+, CD14-, CD19-, CD24-, CD34-, CD45-, HLA-DR-	Blanco et al., 2010 [117]
Human	NPSPCs	CD29+, CD44+, CD105+, CD14-, CD34-, CD45-, HLA-DR-	Shen et al., 2015 [25]
Human	NPSPCs	Tie2+, GD2+, Nanog+, Oct-4+, Sox-2+	Li et al., 2017 [118]
Rat	NPSPCs	CD73+, CD90+, CD105+, CD34-, CD45-	Zhao et al., 2017 [119]
Canine	NPSPCs	CD133+, KI67+, Nanog+, NCAM+, Nestin+, Oct3/4+, Sox2+, Brachyury-	Erwin et al., 2013 [42]
Human	NPSPCs, AFSPCs	CD49a+, CD63+, CD73+, CD90+, CD105+, CD166+, p75 NTR+, CD133/1+, CD34-	Risbud et al., 2007 [39]
Rhesus macaque	NPSPCs, AFSPCs	CD44+, CD90+, CD146+, CD166+, HLA-DR+, CD271-, CD106-, CD29-	Huang et al., 2013 [120]
Rabbit	NPSPCs, AFSPCs	PCNA+, CD166+, C-kit+, Jagged1+, Notch1+	Yasen et al., 2013 [121]
Human, rat, rabbit	AFSPCs	Notch1+, Delta4+, CD117+, STRO-1+, C-kit low, KI67 low	Henriksson et al., 2009 [40]; Henriksson et al., 2012 [41]
Human	AFSPCs	CD29+, CD49e+, CD51+, CD73+, CD90+, CD105+, CD166+, CD184+, CD24+, Stro-1+, Nestin+, NSE+, CD31-, CD34-, CD45-, CD106-, CD117-, CD133-	Feng et al., 2010 [122]
Human	AFSPCs	CD14+, CD29+, CD44+, CD73+, CD90+, CD105+, STRO-1+, CD34-, CD45-	Gruber et al., 2016 [123]
Rabbit	AFSPCs	CD29+, CD44+, CD166+, Oct4+, Nucleostemin+, SSEA-4+, CD4-, CD8-, CD14-	Guo et al., 2018 [124]
Rabbit	AFSPCs	CD29+, CD44+, CD166+, Oct4+, SSEA-4+, CD4-, CD8-, CD14-	Liu et al., 2014 [125]
Human	CEPSCs	CD73+, CD90+, CD105+, CD34-, CD45-, HLA-DR-	Yuan et al., 2018 [126]; Yao et al., 2016 [127]
Human	CEPSCs	CD44+, CD73+, CD90+, CD105+, CD133+, CD166+, Stro-1+, CD14-, CD19-, CD34-, CD45-, HLA-DR-	Liu et al., 2011 [45]; Huang et al., 2012 [50]