Human Umbilical Mesenchymal Stromal Cells Mixed with Hyaluronan Transplantation Decreased Cartilage Destruction in a Rabbit Osteoarthritis Model

Figure 7

Immunohistochemistry of inflammatory markers TNF-α, IL1-β, and IL6 in the cartilage after 12 weeks of experiments. (a) Representative image of IL-1β in the cartilage of normal cartilage (negative control), normal saline control, and treated knee. . (b) The HUCMSC+HA-treated joints show no significantly higher content of IL-1β than the normal saline control joints (). (c) Representative image of IL-6 in the cartilage of normal cartilage (negative control), normal saline control, and treated knee. . (d) The HUCMSC+HA-treated joints show no significantly higher content of IL-6 than the normal saline control joints (). No differences are noted between both groups. (e) Representative image of TNF-α in the cartilage of normal cartilage (negative control), normal saline control, and treated knee. . (f) The HUCMSC+HA-treated joints show no significantly higher content of TNF-α than the normal saline control joints (). No statistical differences are noted between both groups. Ctrl: control.