miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy

<div>miR-20a-ADSC/ADSC treatment delays disease progression and reduces disease severity in murine LN: (a) anti-dsDNA, (b) serum creatinine, and (c) 24 h urine protein. (d–o) Representative images of kidney sections stained with H&amp;E and immunohistochemistry of the normal control group (d, h, and l), lupus group (e, i, and m), ADSC group (f, j, and n), and miR-20a group (g, k, and o). (p) Nephritis severity scores. (q) Measurement of C3- or IgG-positive cells using IOD/area. 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transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg><i>vs.</i> ADSC group. Control: normal control group; lupus: lupus group; ADSC: adipose-derived stem cell group; miR-20a: miR-20a-ADSC group.</div>

Stem Cells International

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Figure 2

Figure 2: miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy 

Figure 2 | miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy 