Review Article

Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration

Table 5

Clinical use of MFSCs.

Cell typeCell application formTissue regenerationReference

PDLSCsPDLSC stem cell assistance in periodontal regeneration technique (SAI-PRT)Periodontal tissue[79, 80]
Autologous PDLSCs, PDLSC pellets, and cell sheet fragmentPeriodontal tissue(ClinicalTrials.gov identifier: NCT01357785, NCT01082822)

DPSCsDPSC rejection medicineAlveolar bone (phase II clinical trial)(cde.org.cn identifier: CXSL1700137)
Autologous DPSC combined advanced therapy medicinal product (ATMP)Dental pulp (early phase 1 clinical trial)(ClinicalTrials.gov identifier: NCT02842515)
Encapsulated DPSCsDental pulp(ClinicalTrials.gov identifier: NCT03102879)
Allogenic DPSCsOsseointegration(ClinicalTrials.gov identifier: NCT02731586)
Leukocyte-platelet-rich fibrin (L-PRF) combined with DPSCsPeriodontal tissue(ClinicalTrials.gov identifier: NCT04641533)
Micrograft-enriched DPSCsPeriodontal tissue(ClinicalTrials.gov identifier: NCT03386877)
DPSC injection medicineBone tissue (osteoarthritis) (early phase 1 clinical study)(ClinicalTrials.gov identifier: NCT04130100)

SCAPDPSCs+mineral trioxide aggregate (MTA)+platelet-rich fibrin (PRF)Odontoblast and dentin[137]

SHEDAutologous SHED pelletDental pulp and periodontal tissue(ClinicalTrials.gov identifier: NCT01814436)
Autogenous human SHED associated with hydroxyapatite/collagenBone tissue (alveolar cleft)(ClinicalTrials.gov identifier: NCT03766217)
SHED injectionLiver tissue (Early phase 1 clinical trial)(ClinicalTrials.gov identifier: NCT03957655)

GMSCsGMSCs from palate soft tissuePeriodontal tissue(ClinicalTrials.gov identifier: NCT03570333)
GMSCs and collagen scaffoldsPeriodontal tissue (phase 1 and phase 2 clinical trial)(ClinicalTrials.gov identifier: NCT03137979)