RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53

Figure 6

RIPK1 maintained mitochondrial homeostasis of bone marrow MSCs via p53. (a) Representative graphs illustrated that the increase of mPTP opening after knockdown of RIPK1 in bone marrow MSCs was significantly reversed by sip53. (b) The quantitative mPTP in bone marrow MSCs was demonstrated by RFI. Data are expressed as the from three independent experiments (, vs. siRIPK1; ). (c) The decrease of mitochondrial ATP production after knockdown of RIPK1 in bone marrow MSCs was significantly reversed by sip53. Values are expressed as the from three independent experiments (, vs. siRIPK1; ). (d) Representative western blots for the expression of PUMA. Histogram analysis showing the relative protein levels of PUMA. Data are presented as the from three independent experiments (, vs. siRIPK1; ).

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