Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model

Figure 3

Behavioral tests through Y-maze and Morris water maze. (a) The number of total arm entries and (b) spontaneous alternations in the Y-maze test. Escape latency during the (c) four-day training period and on the (d) last day and the swimming path of the mouse recorded during the (e) probe test in Morris water maze test. Data represent the and were analyzed by one-way ANOVA. comparison between Aβ and normal; ^# and ^### comparison between MSC and Aβ; ^@ and ^@@@ comparison between NEP-MSC and Aβ; ^$$ comparison between NEP-MSC and normal. SEM: standard error of the mean; ANOVA: analysis of variance; Aβ: Aβ_1-42 injection group; MSC: naïve human umbilical cord-derived mesenchymal stem cell injection group; NEP-MSC: neprilysin-enhanced human umbilical cord-derived mesenchymal stem cell injection group.

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