Intranasally Administered L-Myc-Immortalized Human Neural Stem Cells Migrate to Primary and Distal Sites of Damage after Cortical Impact and Enhance Spatial Learning

Figure 5

Beginning 1 week after TBI or sham injury, adult male rats were IN-administered LM-NSC008 cells ( in 24 μL; or ) or VEH (2% human albumen serum; 24 μL; or ) on post-surgery days 7, 9, 11, 13, 15, and 17 and then were evaluated for the acquisition of spatial learning in a well-established Morris water maze. Mean (±S.E.M.) time(s) to locate the escape platform over days 18–23. vs. . vs. and . Shams did not differ from one another .