Proteomic Analysis of Hypoxia-Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells

Figure 4

Profiling of differentially expressed proteins using GO analysis. (a) GO annotated statistics of differentially expressed proteins. The gene ontology categories of differentially expressed proteins based on biological processes (BP), molecular functions (MF), and cellular components (CC) between the 12-hour hypoxia-induced group and the control group. (b) As for BP, the upregulated (red) differentially expressed proteins were involved in extracellular structure organization, extracellular matrix organization, extracellular matrix disassembly regulation, cell proliferation, and regulation of cell proliferation. The downregulated (green) proteins were mainly enriched in the positive regulation of cell proliferation, biological adhesion, cell adhesion, platelet degranulation, and humoral immune response categories. (c) In terms of MF, the upregulated (red) proteins were mainly annotated in the receptor-ligand activity, receptor regulator activity, signaling receptor binding, calcium ion binding, and growth factor binding categories. Downregulated (green) proteins were mainly enriched in the peptidase regulator activity, extracellular matrix structural constituent, molecular transducer activity, and signaling receptor activity categories.

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