Positively Correlated CD47 Activation and Autophagy in Umbilical Cord Blood-Derived Mesenchymal Stem Cells during Senescence

<div>CD47 expressions and autophagy on UCB-MSCs were downregulated during passages. (a) Representative western blot results revealed autophagy-related protein expressions, CD47, ATG5, ATG12, Beclin1, and LC3B during passaging from P4 to P13. Relative fold changes of protein expressions were normalized to each protein level observed at P4. (b) LC3B-positive cells at different passages (P4, P7, and P13) were monitored by immunostaining. Scale bar 20 <i>μ</i>m. 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Stem Cells International

fig3

Figure 3

Figure 3: Positively Correlated CD47 Activation and Autophagy in Umbilical Cord Blood-Derived Mesenchymal Stem Cells during Senescence 