Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway

<div>Effect of hydrostatic pressure on synthesis of aggrecan of the rabbit notochordal NP and fibrocartilaginous inner AF: (a) aggrecan IHC staining of the notochordal NP under graded hydrostatic pressure (200x); (b) statistic analysis of IHC aggrecan AOD value of the notochordal NP under graded hydrostatic pressure; (c) aggrecan IHC staining of the fibrocartilaginous inner AF under graded hydrostatic pressure (200x); (d) statistic analysis of IHC aggrecan AOD value of the fibrocartilaginous inner AF under graded hydrostatic pressure. <span class="nowrap"><svg height="10.7395pt" id="M13" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 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Stem Cells International

fig3

Figure 3

Figure 3: Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway 