Review Article

Applications of Mesenchymal Stem Cells in Liver Fibrosis: Novel Strategies, Mechanisms, and Clinical Practice

Table 1

Summary of clinical trials using mesenchymal stem cells for the treatment of liver fibrosis.

ClinicalTrials.gov identifierCountryConditionsPhaseEstimated enrollmentAllocation/maskingIntervention modelBiologicalAuto/AlloCell numberCell injection timesCell injection route

NCT02705742TurkeyHCV-related liver cirrhosisI/II5 participantsN/A/open labelSingle group assignmentAT-MSCAutoN/AHepatic artery and peripheral vein
NCT02652351ChinaLiver cirrhosisI20 participantsN/A/open labelSingle group assignmentUC-MSCAlloA single dose of 4Intravenous or hepatic artery
NCT02786017ChinaDecompensated cirrhosisI/II40 participantsRandomized/double (participant, outcome assessor)Parallel assignmentInjectable Collagen scaffold + HUC-MSCsAlloThe total amount was N/Aperipheral vein
NCT03209986ChinaHBV/HCV-related liver cirrhosisN/A200 participantsRandomized/single (outcomes assessor)Parallel assignmentMSCN/A3Peripheral vein
NCT03668145ChinaPrimary biliary cirrhosisN/A140 participantsRandomized/quadruple (participant, care provider, investigator, outcome assessor)Parallel assignmentMSCN/A3Peripheral vein
NCT03529136ChinaDecompensated cirrhosisII252 participantsNonrandomized/open labelParallel assignmentUC-MSCAllo2~4Peripheral vein
NCT03626090SingaporeLiver cirrhosisI/II20 participantsN/A/open labelSingle-group assignmentBM-MSCAutoN/APeripheral vein
NCT03826433ChinaDecompensated hepatitis b cirrhosisI20 participantsNonrandomized/open labelParallel assignmentUC-MSCAlloN/APeripheral vein
NCT03945487ChinaDecompensated cirrhosisII200 participantsRandomized/open labelParallel assignmentUC-MSCAllo3Intravenous
NCT03838250United StatesAlcoholic liver cirrhosisI10 participantsN/A/open labelSingle-group assignmentCellgramâ„¢ (BM-MSC)AutoN/AHepatic artery
NCT04243681IndiaDecompensated cirrhosisIV5 participantsNonrandomized/open labelParallel assignmentCD 34 and MSCAutoN/AN/AHepatic artery
NCT03460795ChinaDecompensated cirrhosisI/II30 participantsN/A/open labelSingle-group assignmentMSCs and TregsN/AN/AN/AN/A
NCT01454336IranLiver fibrosis/decompensated cirrhosisI3 participantsN/A/open labelSingle-group assignmentMSCAutoN/AN/AN/A
NCT01220492ChinaLiver fibrosisI/II266 participantsRandomized/open labelParallel assignmentUC-MSCN/AN/AN/AN/A
NCT01342250ChinaDecompensated cirrhosisI/II20 participantsRandomized/open labelParallel assignmentUC-MSCN/AN/AN/AN/A
NCT01499459TurkeyLiver cirrhosisN/A25 participantsN/A/open labelSingle-group assignmentMSCAutoN/AN/AN/A
NCT01233102ChinaLiver cirrhosisI/II200 participantsRandomized/single (single (participant))Parallel assignmentMSCN/AN/AN/AHepatic artery or vein
NCT01741090Republic of KoreaAlcoholic liver cirrhosisII12 participantsN/A/open labelSingle-group assignmentMSCN/AN/AN/AN/A
NCT00976287ChinaLiver cirrhosisII50 participantsRandomized/single (single (participant))Parallel assignmentBM-MSCAutoN/AN/AHepatic artery
NCT00993941ChinaLiver cirrhosisII60 participantsNonrandomized/open labelParallel assignmentBM-MSCN/AN/AN/AN/A
NCT01728727ChinaHBV-related liver cirrhosisI/II240 participantsRandomized/open labelParallel assignmentUC-MSCN/AN/AN/AN/A
NCT01483248ChinaLiver fibrosis/liver cirrhosisI/II50 participantsRandomized/open labelSingle-group assignmenthMB-MSCN/AN/AN/AN/A
NCT03254758JapanDecompensated cirrhosisI/II15 participantsN/A/open labelSingle-group assignmentMSCN/AN/AN/AN/A
NCT04357600IndonesiaLiver cirrhosisI/II12 participantsN/A/open labelSingle-group assignmentUC-MSCN/AN/AN/AN/A
NCT01573923ChinaLiver cirrhosisI/II320 participantsNonrandomized/open labelParallel assignmentUC-MSCN/AN/AN/AN/A
NCT01224327ChinaLiver cirrhosisI/II50 participantsRandomized/open labelParallel assignmentUC-MSCN/AN/AN/AHepatic artery
NCT04522869VietnamPrimary Biliary cirrhosisI/II34 participantsNonrandomized/open labelParallel assignmentUC-MSCN/AN/AN/AN/A
NCT01662973ChinaPrimary biliary cirrhosisI/II100 participantsRandomized/open labelParallel assignmentUC-MSCN/AN/AN/AN/A
NCT02943889EgyptLiver cirrhosisI/II40 participantsNonrandomized/open labelParallel assignmentMSCN/AN/AN/AN/A
NCT00476060IranDecompensated cirrhosisII36 participantsRandomized/double (participant, outcome assessor)Parallel assignmentMSCAutoN/AN/AN/A
NCT01440309ChinaPrimary biliary cirrhosisI20 participantsRandomized/open labelParallel assignmentMSCAlloN/AN/AN/A