Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway

<div>Metformin inhibits miR-34a-3p expression and activates the AMPK/mTOR signaling pathway in DPSCs. Young and aging DPSCs were treated with 100 <i>μ</i>M metformin for 48 h. (a) Relative expression levels of miR-34a-3p and (b) CAB39 were determined by RT-qPCR. (c) Representative blots of p-AMPK, AMPK, p-mTOR, and mTOR protein expression levels. (d) Quantitative analysis of the proportion of p-AMPK/AMPK and p-mTOR/mTOR. 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Stem Cells International

fig4

Figure 4

Figure 4: Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway 

Figure 4 | Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway 