Application of Stem Cell Therapy for ACL Graft Regeneration

Table 3

Published clinical trials of stem cell therapy for ACL graft regeneration.

Author	Cell resource	Patient	Follow-up	Evaluation	Outcome	Other outcomes
Wang et al. [112]	BMSCs	11 vs. 6	2 y	Adverse event; pain; function; MRI; LifeQ	+	Less pain, symptoms, bone expansion, joint space narrowing, and cartilage volume loss
Silva et al. [149]	BMSCs	20 vs. 23	1 y	MRI	-	No signal-to-noise ratio difference
Alentorn-Geli et al. [115]	ADSCs	20 vs. 19	1 y	Pain; function; MRI	-
Park et al. [116]	hUCB-MSCs	10 vs. 10 vs. 10^#	2 y	Adverse event; KT; function; arthroscopy	—	Safe but no clinical advantage

The experimental group (ACLR+stem cell) vs. the negative control group (ACLR); ^#the experimental group (ACLR+stem cell+HA) vs. the negative control group (ACLR) vs. the positive control group (ACLR+HA).