miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages

Figure 6

Overexpression of miR-375 can lead to changes in multiple signaling pathways during pancreatic development. (a) The line chart shows the expression level of some differentially expressed genes occupying a central position in protein-protein interaction networks. The red line represents the control group and the green line represents the overexpression group, the abscissa represents the differentiation time, and the ordinate represents the expression of the gene in different differentiation stages (normalized to TPM). (b) The protein-protein interaction network obtained from the STRING database. Each circle represents a gene, and each edge represents a possible interaction between two genes. The size of the circular area represents the importance of the gene in the network. The highlighted genes (black characters on a yellow background) play an important role in the network and need to be analyzed individually and are plotted in (a).

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