Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis

Table 2

The identification of proteins related to tissue regeneration.

Anti-inflammation	Anti-apoptosis	ECM-cell interactions	Homeostasis	Inhibition of MMPs	Regeneration of chondrocytes
Inflammatory condition
ANXA1 [59, 60]; IL-11 [61]; TSP-1 [62, 64, 69]; TSG-6 [6, 65, 66]; NID1 [67]; TMSB4X [68]	LTF [70]; TMSB4X [68]; LIF [71]; CALR [72]	BGN [73]; COL1A1 [74]; IGFBP3 [75]; DCN [73]; LUM [73]; FBN1 [63]; FN1 [63, 75]; VCL [76]; TSP-1 [63]; TSP-2 [63]; TFPI2 [77]	ANXA1 [59, 60]; VIM [78]	TSG-6 [6, 65, 66]; IGFBP3 [75]; INHBA [80]; TSP-1 [62, 64, 69]; TSP-2 [81, 82]; SERPINE2 [91]	TSP-2 [81, 82]; LTF [70]; MIF [83]
Normal condition
NID1 [67]; SERPINE1 [79]; A2M [84, 85]	LTF [70]; ACTG1 [74]; VTN [74]	CTGF [86]; TGFBI [87]; VTN [74]; BGN [73]; COL1A1 [74]; IGFBP3 [75]; DCN [73]; LUM [73]; FBN1 [63]; FN1 [63, 75]; VCL [76]; TSP-2 [63]	VIM [78]	CYR61 [88]; SOD1 [89]; SPOCK1 [90]; A2M [84]; IGFBP3 [75]; TSP-2 [81, 82]	TSP-2 [81, 82]; LTF [70]; MIF [83]