Stem Cells International / 2021 / Article / Tab 4 / Review Article
The Gingiva from the Tissue Surrounding the Bone to the Tissue Regenerating the Bone: A Systematic Review of the Osteogenic Capacity of Gingival Mesenchymal Stem Cells in Preclinical Studies Table 4 Summary of findings for in vivo studies (methodology).
No. Author and year of publication Animal model Experimental groups/number Stem cells Bone defect Species/strain Sex/age (w) Weight Source of interest Other sources Positive control Negative control Source Isolation method Dose Delivery method Scaffold or carrier Fate tracing Site & diameter (mm) Induction method 1 Al-Qadhi et al. (2020) [48 ] New Zealand rabbit M 24 2.5-3 kg GMSCs/9 BMSCs/9 — Cell-free scaffold /9 Rabbit Enzymatic Local NanoBone PKH26 Tibia/6.0 Surgical 2 Sun et al. (2019) [67 ] C57BL/6J mice NM 8 21.08 g GMSCs/18 — — Cell-free medium/18 Human Enzymatic Systematic α -MEMGFP Maxilla/NM Disease induced by ligation 3 Xu et al. (2014) [68 ] C57BL/6J mice M 7 NM GMSCs/18 — — Cell-free medium/18 Human Enzymatic Systematic α -MEMGFP Mandible/1.5 Surgical 4 Moshaverinia et al. (2014) [66 ] Beige nude mice NM 20 NM GMSCs/4 PDLSCs/4 BMSCs/4 Cell-free scaffold/4 Human Enzymatic Local RGD-modified alginate — Calvaria/0.5 Surgical 5 Yu et al. (2012) [69 ] Beagle dogs M 4 10-11 kg GMSCs/4 — — Cell-free scaffold/contralateral side Human Enzymatic Local Cell sheet GFP Mandible/5.0 Surgical 6 Wang et al. (2011) [52 ] SD rats F 6-8 160-180 g GMSCs/5 — — Cell-free matrix/5 Human Enzymatic Local Type 1 collagen gel GFP Mandible/1.0 Surgical GMSCs/3 Cell-free matrix/contralateral side Calvaria/5.0
