Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells

Figure 6

Immune response 21 days post transplantation of ABASCs and OASCs in the NaIO3 mice model. (a) Immunohistochemistry pictures of CD45+ staining in NaIO3-treated mice compared to nontreated mice revealed the infiltration of CD45+ cells in the retinas of NaIO3-treated mice compared to controls. (b) Immunohistochemistry pictures of CD45-Iba1 costaining. (b, c) Quantification of the number of CD45+ cells revealed a higher infiltration of leucocytes in ABASC-treated mice compared to PBS treated mice (). (b)–(d) Quantification of the number of Iba1+ cells revealed a higher infiltration of Iba1+ cells in ABASC-treated mice compared to OASC-treated mice and to PBS-treated mice (). (b)–(e) Most of CD45+ cells expressed Iba1 in all treated groups. ONL: outer nuclear layer; INL: inner nuclear layer; RGC: retinal ganglion layer. . For each group of mice, . Data are represented as .

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