lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis

<div>KCNQ1OT1 can sponge miR-141-5p. (a) KCNQ1OT1 and miR-141-5p have potential binding sites. (b, c) As dual-luciferase reporter assay showed, miR-141-5p weakened the luciferase activity in the KCNQ1OT1-WT group obviously, but the activity of luciferase reporters containing KCNQ1OT1-MUT was not changed significantly in both HEK293 and primary osteoblasts. (d) LV-KCNQ1OT1-Exos blocked the inhibitory effect of miR-141-5p on the luciferase activity of reporters containing KCNQ1OT1-WT compared with ADSC-Exos and LV-NC-Exos. (e) KCNQ1OT1 suppressed the expression of miR-141-5p, but the sh-KCNQ1OT1 increased that. 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Stem Cells International

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Figure 6

Figure 6: lncRNA-KCNQ1OT1: A Potential Target in Exosomes Derived from Adipose-Derived Stem Cells for the Treatment of Osteoporosis 