|
| Sources of exosomes | Cargos | Species/models | Outcome | Ref. |
|
| hWJMSCs | miR-30 | SD rats/left kidney ischemia for 45 mins | Inhibit DRP1
Antiapoptosis | [103] |
| miR-15, miR-16 | SD rats/left kidney ischemia for 60 mins | Inhibit CX3CL1
Anti-inflammation | [104] |
| _ | Rats/left kidney ischemia for 45 mins
NRK-52E cells/hypoxia for 6 h | Activate Nrf2/ARE pathway
Antioxidation | [105] |
|
| hucMSCs | HGF mRNA | SD rats/left kidney ischemia for 1 h | Activate ERK 1/2 pathway
Antiapoptosis | [106] |
| _ | SD rats: 6 mg/kg cisplatin
NRK-52E cells/5 μM cisplatin for 6 h | Activate ERK 1/2 pathway
Antiapoptosis | [107] |
| _ | C57BL/6 mice/CLP surgery | Inhibit NF-κB pathway
Anti-inflammation | [108] |
| _ | SD rats/unilateral ureteral obstruction
NRK-52E cells/TGF-β1 | Inhibit TLR4/NF-κB pathway
Anti-inflammation | [109] |
| CK1δ, β-TRCP | SD rats/unilateral ureteral obstruction | Inhibit YAP activity
Antifibrosis | [110] |
| miR-125b-5p | C57BL/6 mice/bilateral kidneys ischemia for 30 mins
HK-2 cells/hypoxia for 12 h | Inhibit p53
Antiapoptosis | [111] |
|
| hADMSCs | _ | C57BL/6 mice/left kidney ischemia for 30 mins | Upregulate Sox9
Antifibrosis | [112] |
| _ | C57BL/6 mice/CLP surgery | Activate SIRT1
Anti-inflammation, Antiapoptosis | [113] |
|
| hUSCs | miR-146a-5p | SD rats/left kidney ischemia for 45 mins
HK-2 cells/hypoxic medium 48 h | Downregulate IRAK1
Inhibit NF-κB pathway
Anti-inflammation | [114] |
| miR-216a-5p | SD rats/left kidney ischemia for 45 mins
HK-2 cells/hypoxic medium 1 h | Downregulate PTEN
Antiapoptosis | [115] |
|
| hP-MSCs | miR-200a-3p | FVB mice/right kidney ischemia for 50 mins | Activated Keap1-Nrf2 pathway
Antioxidation | [116] |
|
| Mouse BMMSCs | CCR2 | BALB/c mice/left kidney ischemia for 1 h | Absorb CCL2
Anti-inflammation | [117] |
|
| Mouse ADMSCs | miR-486 | C57BL/KsJ db/db mice | Inhibit Smad1/mTOR pathway
Promote autophagy
Antiapoptosis | [118] |
|
| GI-MSCs | miRNAs | SCID mice/left kidney ischemia for 35 mins | Promote proliferation | [119] |
|
| RAPCs | miR-218, Robo-1 | C57BL/6 mice/bilateral kidney ischemia for 30 mins | Promote migration | [120] |
|
| ECFCs | miR-486-5p | FVB mice/bilateral kidney ischemia | Downregulate PTEN
Activate Akt pathway | [121] |
|
| EPCs | miR-126-3p
miR-126-5p | CD-1 outbred mice/CLP | Downregulate HMGB1 and VCAM1 | [122] |
|
