Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy

<div>Characterization of hiPSCs and hiPSC-CMs. (a) Immunostaining of hiPSCs before differentiation: Oct4 (green), SSEA4 (red), Sox2(green), and DAPI (blue). (b) Immunostaining of hiPSC-CMs: <i>α</i>-actinin (green), cTnT (red), and DAPI (blue). Oct4: octamer-binding transcription factor 4; SSEA4: stage-specific embryonic antigen 4; Sox2: SRY-box transcription factor 2.</div>

Stem Cells International

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Figure 2

Figure 2: Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy 