Review Article

Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases

Figure 3

Transcriptomic network related to the quality and freshness of starved human bone marrow-derived mesenchymal stem cells (hBM-MSCs). (a) Analysis of the transcriptomic network with prediction using Ingenuity Pathway Analysis based on starved hBM-MSCs in phosphate-buffered saline for 12 h. Analysis of the transcriptomic network based on a combination of (b) N-acetyl-L-cysteine (NAC) and (c) glutathione (GSH) administered for 12 h. The analysis involved a . Green and red nodes indicate genes that were up and downregulated, respectively, compared to control levels. Orange and blue arrows indicate in silico prediction of function as activation and inhibition, respectively. Details of the shape and color, which were created with Ingenuity Systems (http://www.ingenuity.com), are described in the legends.
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