Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform

Figure 4

Three drug release patterns. (a) Exocytosis: either free Dox or Dox/SiO₂ NPs were secreted by MAs for glioblastoma treatment. Reproduced with permission [18]. Copyright 2018. John Wiley and Sons. (b) Cell disintegration I: Abraxane-encapsulated NEs disintegrated and formed the neutrophil extracellular traps to kill gastric cancer. Reproduced with permission [38]. Copyright 2018. John Wiley and Sons. (c) Cell disintegration II: Dox-encapsulated and Ce6-backpacked RBCs were disintegrated by photoradiation for breast cancer. Reproduced with permission [46]. Copyright 2017. American Chemical Society. (d) Cell-drug dissociation: SN-38 was dissociated from the T cell membrane into lymphoma cells. Reproduced with permission [12]. Copyright 2015. American Association for the Advancement of Science.

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